TABLE 2.
Predominant genetic mutations (present in at least 5 isolates) identified in 494 isolates
| First-line drugs |
Second-line drugs |
||||
|---|---|---|---|---|---|
| Drug | Gene | Mutationsa | Drug | Gene | Mutationsa |
| Isoniazid | katG | p.S315X, Indels | Aminoglycosides | rrs | n.A1401G, Indels |
| fabG1-promoter | n.C-15T, n.T-8C | Ethionamide | fabG1- promoter | n.C-15T, n.T-8C | |
| inhA | p.S94A | inhA | p.S94A, p.I21T | ||
| Rifampicin | rpoB | p.S450X, p.L430P, p.H445X, p.D435X, p.Q432L, Indels | ethA | Indels | |
| Ethambutol | embB | p.M306X, p.Q497R, p.T1082A, p.G406X, p.D354A, p.D1024N | Fluoroquinolones | gyrA | p.A90V, p.D94X, |
| embA | n.C-12T, n.C- 16× | Streptomycin | rpsL | p.K43R, p.K88R | |
| Pyrazinamide | pncA | Indels, p.G132A, p.L27P, p.I5S, p.T76P | rrs | n.A1401G, n.C517T, n.A514C | |
a
Amino acid changes are represented with the prefix “p” and nucleotide changes with the prefix “n”. The letter “X” indicates codons/nucleotide positions where more than one change was observed. “Indels” refer to small insertions and deletions observed in the genes.