TABLE 4.
Detectable CMV viremia or disease and the associated UL97 and UL54 single nucleotide polymorphisms of recipients in this studya
| CMV IgG | Daysb | Viremia, IU/mLc | Disease, IU/mLc | Symptoms | SNP(s) in: |
|
|---|---|---|---|---|---|---|
| UL97 | UL54 | |||||
| During prophylaxis | ||||||
| D+/R− | 63 | 3,340 | Asymptomatic | Q19E, T75A, S108N, Q126L, A594V, C603W | A647V, N898D, A1108T, T1122A | |
| D+/R+ | 75 | <250 | Asymptomatic | — | — | |
| D+/R− | 114 | Esophagitis (<250) | Odynophagia, esophageal ulceration, intermittent fever | — | — | |
| Postprophylaxis during the first yr of transplant | ||||||
| D+/R− | 250 | Colitis (33,050) | Diarrhea, vomiting | T75A | S655L, N685S, L897S, N898D, R984H, A1108T | |
| D+/R− | 208 | Gastritis (2,720) | Nausea, reduced oral intake | T75A | N898D, A1108T, S1235T | |
| D+/R− | 358 | Syndrome (236,000) | Systemic symptoms of leukopenia, transaminitis, diarrhea | T75A, Q126L, H469Y | A614V, A1108T | |
| D+/R− | 293 | Colitis (312,500) | Vomiting, diarrhea, fever | T75A, R112C, R112H, Q126L | S24L, S655L, N685S, G874R, L897S, N898D, A1108T, T1122A | |
| D+/R+ | 205 | <250 | Asymptomatic | — | — | |
| D+/R+ | 175 | <250 | Asymptomatic | — | — | |
a
UL97 and UL54 reads were mapped against the CMV strain Merlin genome to assign variants (GenBank accession number NC_006273). Ganciclovir resistance mutations are shown in bold, mutations associated with ganciclovir resistance are shown in bold with italics, and mutations with unknown resistance phenotypes are underlined. —, gene not amplified or detected upon sequencing data analysis.
b
Days posttransplant when viremia was first detected.
c
Peak viral load is shown.