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Deleting GCN5 in C. glabrata leads to reduced resistance development under antifungal pressure. Micafungin resistance (A) and fluconazole resistance (B) were measured in both WT and gcn5Δ cells at the 24-h and 48-h time points of the time-kill assay. Cells were plated onto YPD plates containing micafungin (0.25 μg/mL) and fluconazole (512 μg/mL), respectively. The plots show mean resistant colony frequencies ± standard deviations (SD) from ≥3 independent experiments.
