Supplementation with IPA-altered gut microbiota composition in septic mice. (A) Composition of alpha diversity was accessed by the Shannon, Simpson, Chao, and Ace indices in feces. (B, C) Scatterplots of PCoA showed beta diversity of feces. Venn diagram of the number of common and unique operational taxonomic units (D) and variation in the relative abundance of samples at the family level (E) in each group were showed. n = 6; *, P < 0.05; **, P < 0.01; ***, P < 0.001; #, P > 0.05.