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. 2022 Apr 18;10(3):e02625-21. doi: 10.1128/spectrum.02625-21

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Copyright © 2022 Xin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — Bioinformatics analysis for hsa-miR-16-5p and hsa-miR-451a. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was used to annotate and classify the functions of target genes of the selected miRNAs in the pathways. (A) A total of 14 overlapping signaling pathways for the two miRNAs were obtained by VENNY analysis. (B) Target genes involved in the mitogen-activated protein kinase (MAPK), mammalian (mechanistic) target of rapamycin (mTOR), and phosphatidylinositol 3′-kinase–Akt (PI3K-Akt) signaling pathways were selected for miRNA-gene network construction. Pink color represents miRNAs and blue color represents genes.