TABLE 3.
Predicting value of microRNAs on active TB developmenta
| MicroRNAs | Youden index | Sensitivity, % (95% CI) | Specificity, % (95% CI) |
|---|---|---|---|
| hsa-miR-16-5p | 0.269 | 68.49 (57.14 to 78.00) | 58.44 (47.29 to 68.79) |
| hsa-miR-451a | 0.293 | 38.36 (28.05 to 49.83) | 90.91 (82.40 to 95.53) |
| hsa-miR-16-5p + hsa-miR-451a | 0.293 | 38.36 (28.05 to 49.83) | 90.91 (82.40–95.53) |
| hsa-miR-16-5p + co-variablesb | 0.545 | 73.97 (62.89–82.66) | 80.52 (70.31–87.82) |
| hsa-miR-451a + co-variablesb | 0.600 | 80.82 (70.34–88.22) | 79.22 (68.88–86.78) |
| hsa-miR-451a + hsa-miR-16-5p + co-variablesb | 0.598 | 76.71 (65.83–84.92) | 83.12 (73.23–89.86) |
a
TB, tuberculosis; CI, confidence interval.
b
Youden index and corresponding sensitivity and specificity were calculated based on predicted probability, generated by putting co-variables (BMI, with prior history of TB) and hsa-miR-16-5p or hsa-miR-451a together in a logistic regression model.