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. 2022 May 31;10(3):e00574-22. doi: 10.1128/spectrum.00574-22

TABLE 1.

AMK and CLA resistance of all MABC isolatesa

Genotype Drug MIC range (μg/mL) MIC50 MIC90 No. of strains distributed at the MIC (μg/mL)
0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 8 16 32 64 128 256
MAA AMK 1–128 2 32 0 0 0 0 0 0 26 16 10 8 6 5 0 5 0
CLA (Day 3) 0.06–16 0.12 1 0 0 25 17 14 10 6 3 0 0 1 b 0 0 0 0
CLA (Day 14) 0.06–32 8 32 0 0 5 6 6 8 5 4 3 6 13 19 0 0 0
MAM AMK 1–64 2 16 0 0 0 0 0 0 8 6 4 3 4 1 1 0 0
CLA (Day 3) 0.06–32 0.12 0.25 0 0 10 7 6 2 1 0 0 0 0 1 b 0 0 0
CLA (Day 14) 0.06–2 0.25 0.5 0 0 3 7 10 3 2 1 0 0 0 0 0 0 0
Total AMK 1–128 2 32 0 0 0 0 0 0 34 22 14 11 10 6 1 5 0
CLA (Day 3) 0.06–32 0.12 0.5 0 0 35 24 20 12 7 3 0 0 1 b 1 b 0 0 0
CLA (Day 14) 0.06–32 1 32 0 0 8 13 16 11 7 5 3 6 13 19 0 0 0
a

CLA = clarithromycin; AMK = amikacin; MABC = Mycobacterium abscessus complex; MAA = M. abscessus subsp. abscessus; MAM = M. abscessus subsp. massiliense. Bold font indicates the drug-resistant strain.

b

Indicates inducible resistance.