TABLE 1.
AMK and CLA resistance of all MABC isolatesa
Genotype | Drug | MIC range (μg/mL) | MIC50 | MIC90 | No. of strains distributed at the MIC (μg/mL) |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | |||||
MAA | AMK | 1–128 | 2 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 26 | 16 | 10 | 8 | 6 | 5 | 0 | 5 | 0 |
CLA (Day 3) | 0.06–16 | 0.12 | 1 | 0 | 0 | 25 | 17 | 14 | 10 | 6 | 3 | 0 | 0 | 1 b | 0 | 0 | 0 | 0 | |
CLA (Day 14) | 0.06–32 | 8 | 32 | 0 | 0 | 5 | 6 | 6 | 8 | 5 | 4 | 3 | 6 | 13 | 19 | 0 | 0 | 0 | |
MAM | AMK | 1–64 | 2 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 6 | 4 | 3 | 4 | 1 | 1 | 0 | 0 |
CLA (Day 3) | 0.06–32 | 0.12 | 0.25 | 0 | 0 | 10 | 7 | 6 | 2 | 1 | 0 | 0 | 0 | 0 | 1 b | 0 | 0 | 0 | |
CLA (Day 14) | 0.06–2 | 0.25 | 0.5 | 0 | 0 | 3 | 7 | 10 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Total | AMK | 1–128 | 2 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 34 | 22 | 14 | 11 | 10 | 6 | 1 | 5 | 0 |
CLA (Day 3) | 0.06–32 | 0.12 | 0.5 | 0 | 0 | 35 | 24 | 20 | 12 | 7 | 3 | 0 | 0 | 1 b | 1 b | 0 | 0 | 0 | |
CLA (Day 14) | 0.06–32 | 1 | 32 | 0 | 0 | 8 | 13 | 16 | 11 | 7 | 5 | 3 | 6 | 13 | 19 | 0 | 0 | 0 |
CLA = clarithromycin; AMK = amikacin; MABC = Mycobacterium abscessus complex; MAA = M. abscessus subsp. abscessus; MAM = M. abscessus subsp. massiliense. Bold font indicates the drug-resistant strain.
Indicates inducible resistance.