TABLE 4.
Univariate and multivariate analyses of clinical factors associated with the development of colistin resistance in CRKP strains during colistin treatmenta
| Variable | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 0.833 | |||
| Male sex | 0.30 (0.07–1.23) | 0.085 | ||
| LOS before initial CRKP isolation | 0.035 | |||
| Immunosuppression | 3.87 (1.08–13.90) | 0.049 | ||
| Colistin-tigecycline combination therapy | 0.35 (0.14–0.87) | 0.005 | 0.17 (0.05–0.62) | 0.008 |
a
CRKP, carbapenem-resistant Klebsiella pneumoniae; OR, odds ratio; CI, confidence interval; LOS, length of hospital stay.