FIG 2.
Compounds that inhibit the activity of the deformed wing virus (DWV) 3C protease (3Cpro). Protease activity of DWV 3Cpro in the presence of increasing concentrations of rupintrivir, ebselen, disulfiram, GC376, carmofur, 6,7-dichloroquinoline-5,8-dione, quercetin, and zinc. Ebselen, disulfiram, carmofur were tested in the absence (blue line) or presence (red line) of 2 mM dithiothreitol (DTT). Other compounds were tested in the presence of DTT. All data (n = 3) are shown at the indicated concentrations.