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. Author manuscript; available in PMC: 2023 Jan 27.
Published in final edited form as: Annu Rev Med. 2021 Nov 18;73:483–499. doi: 10.1146/annurev-med-042320-015952

Figure 1.

Figure 1

Staging and progression of type 1 diabetes (T1D). Multiple stages are recognized in the development of T1D that are defined by the appearance of single or multiple autoantibodies (Aabs) and by dysglycemia stages. Virus infection triggers or other environmental triggers can occur in multiple stages, and multiple triggers may be commonly required to produce the clinical onset of T1D.