Table 2.
Demographic, clinical, bio-humoural, echocardiographic characteristics at follow-up of patients without implantable cardioverter-defibrillator (ICD) indications at follow-up despite having ICD indication criteria at baseline
| Variables | Overall (n = 113) | No ICD indication at follow-up (n = 69) | ICD indication at follow-up (n = 44) | P-value | Missing data (%, n) |
|---|---|---|---|---|---|
| BMI | 27 ± 4 | 28 ± 5 | 26 ± 4 | 0.11 | — |
| sBP (mmHg) | 120 [CI: 110; 125] | 120 [CI: 110; 125] | 110 [CI: 60; 75] | 0.36 | 2 (2) |
| HR (b.p.m.) | 65 [CI: 60; 75] | 65 [60; 75] | 68 [CI: 68; 75] | 0.27 | 3 (3) |
| BNP (pg/L) | 159 [CI: 80; 382] | 95 [CI: 51; 143] | 195 [CI: 111; 428] | 0.22 | 2 (2) |
| NT-proBNP (pg/L) | 402 [CI: 177; 860] | 300 [CI: 112; 666] | 875 [CI: 381; 5605] | 0.33 | |
| Creatinine (mg/dL) | 1.09 ± 0.34 | 1 ± 0.3 | 1.14 ± 0.4 | 0.28 | 5 (4.5) |
| eGFR (mL/min) | 74 ± 23 | 77 ± 22 | 68 ± 24 | 0.08 | 5 (4.5) |
| Maximum LAVi (mL/m2) | 43 ± 18 | 38 ± 14 | 51 ± 20 | 0.001 | 2 (2) |
| LVEDVi (mL/m2) | 87 ± 34 | 75 ± 21 | 107 ± 40 | <0.0001 | — |
| LVESVi (mL/m2) | 58 ± 28 | 45 ± 16 | 76 ± 32 | <0.0001 | — |
| LVEF (%) | 37 ± 8 | 42 ± 6 | 29 ± 5 | <0.0001 | — |
| E/A | 0.8 [0.63; 1] | 0.8 [0.63; 0.99] | 0.75 [0.6; 1.2] | 0.33 | 4 (3.5) |
| E/E′ | 11 [9; 12] | 10 [8; 12] | 11 [9; 16] | 0.03 | 4 (3.5) |
| Mitral regurgitation >2 | 33% (28) | 23% (17) | 44% (35) | 0.01 | 8 (7) |
| sPAP (mmHg) | 30 [25; 36] | 28 [24; 35] | 34 [26; 41] | 0.01 | 10 (10) |
| Tricuspid s′ (m/s) | 0.16 ± 0.2 | 0.16 ± 0.1 | 0.17 ± 0.2 | 0.7 | 10 (10) |
| TAPSE (mm) | 20 ± 3.8 | 21 ± 4 | 19 ± 4 | 0.03 | 8 (7) |
| LV GLS (%) | -11.8 ± 3 | -12.8 ± 3 | -10.2 ± 3 | <0.0001 | 2 (2) |
BMI, body mass index; BNP, brain natriuretic peptide; CI, confidence interval; E/A, early diastolic wave/late diastolic wave by pulsed-wave Doppler; E/E′, early diastolic wave by pulsed wave Doppler/average early diastolic wave by tissue-Doppler imaging in the three points of mitral annulus descent; eGFR, estimated glomerular filtration rate; GLS, global longitudinal strain; HR, heart rate; LAVi, left atrial volume index; LV, left ventricular; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESVi, left ventricular end-systolic volume indexed; NT-proBNP, N-terminal-pro-BNP; sBP, systolic blood pressure; sPAP, pulmonary artery systolic pressure; TAPSE, tricuspid annular plane systolic excursion. Significant p values are indicated with bold numbers.