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Location and natural frequency of mutations improving CIS43. (a) Sequences of improved CIS43 variant antibodies are shown along with the heavy (top) and light (bottom) antibody V-gene mutational profiles. We define a rare mutation as a frequency <0.5% in human immune repertoires. (b) Frequencies of amino acid mutations in the context of their respective germline V-gene, reported from cAb-Rep server (Guo et al., 2019).
