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. 2022 Jun 23;219(8):e20220323. doi: 10.1084/jem.20220323

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© 2022 Banach et al.

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Figure S3. — Multi-mutation screening enhances understanding of CIS43 sequence-function relationships. (a) Multi-mutation sequence distribution in pre-sort multi-mutation libraries, and after four rounds of screening for high-affinity variants. (b) Bioinformatic analyses of multi-mutation sequence ERs vs. prevalence after four rounds of FACS revealed the relationship between dominant mutant sequences (red) vs. unmutated CIS43 sequences (cyan) after high-affinity enrichment against fl_PfCSP, NTDS_5/3_CSP, Pep21, Pep25, and Pep29 antigens.