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. 2022 Jun 28;6(7):e740. doi: 10.1097/HS9.0000000000000740

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Dietary habits maintain a healthy HSC pool. Vitamin C (Ascorbate) is one of the most enriched metabolites in HSCs and decreased with differentiation. In homeostasis, Vitamin C regulates the balance between self-renewal and differentiation by promoting Tet2 activity. Vitamin A is crucial to maintain HSC quiescence, since Vitamin A-free diet leads to HSCs exhaustion and disrupted re-entry into dormancy. Dietary supplementation with the NAD⁺ precursor nicotinamide riboside, a form of vitamin B3, improves HSC function reducing mitochondrial metabolism. Icons created with BioRender.com. HSC = hematopoietic stem cell.