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. 2022 Jun 15;13:930470. doi: 10.3389/fphar.2022.930470

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Copyright © 2022 Hishinuma, Narita, Obuchi, Ueda, Saito, Tadaka, Kinoshita, Maekawa, Mano, Hirasawa and Hiratsuka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic pathway of 5-fluorouracil and uracil. 5-Fluorouracil and uracil are catabolized by dihydropyrimidine dehydrogenase, dihydropyrimidinase, and β-ureidopropionase.