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. 2022 Jun 29;8(26):eabm3145. doi: 10.1126/sciadv.abm3145

Table 2. Site optimization—Measured outcomes of recipient diabetic NSG mice.

AUC, area under the curve; n/a, not assessed.

Site EM CC or NK Dose
(k IEQ)
Median reversal
time (day)
Mean
postoperative
glucose (mg/dl)
POD 30 IPGTT
AUC
(mg/dl*min)
POD 54 IPGTT
AUC
(mg/dl*min)
Mean C-peptide
(ng/ml)
Fat pad NK 2 7.5 286 ± 98 25,936 ± 3,155 37,581 ± 766 1.28 ± 0.64
4 1.5 201 ± 118 31,990 n/a 1.68 ± 1.21
EM CC 2 21 435 ± 89 36,281 ± 6,995 28,435 ± 8,007 0.56 ± 0.40
4 1 195 ± 82 18,003 ± 5,218 5,847 ± 1,993 1.14 ± 0.85
Intramuscular EM CC 4 Undefined 360 ± 142 29,351 ± 5,870 29,431 ± 6,467 1.55 ± 0.99
Subcutaneous 8 2.5 326 ± 117 15,253 ± 6,421 n/a 1.57 ± 1.20