Table 1.

Development of MetS traits in selected animal models.

	Elevated blood pressure (hypertension)	Adiposity/obesity	Hyperglycemia/glucose intolerance/insulin resistance	Elevated triglycerides	Reduced HDL/increased total cholesterol
Rodent
Diet induced (i) HFD-fed C57Bl/6 [16]		+	+	+	+
(ii) High fructose diet-fed Wistar rats [34]	+	+	+	+	+
Monogenic mutants (i) ob/ob mice [58, 61]	+	++	+	+	+
(ii) db/db mice [58, 61]		+	++	+	+
Drosophila
Diet-induced (i) HFD-fed flies [53]		+	+	+
(ii) High sucrose fed flies [47]		+	+	+
Monogenic mutants (i) bmm mutant [69]		+		+
(ii) Mutants in insulin-like peptides (dILPs) [42–44]			+	+