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. 2022 Jun 22;2022:7020774. doi: 10.1155/2022/7020774

Figure 4.

Figure 4

FGF7 acted as a key effector for miR-107 in NSCLC cell. (a) FGF7 levels were examined by RT-qPCR in A549 cells transiently transfected with pcDNA3.1 (EV) and pcDNA3.1-FGF7 (FGF7). ∗∗∗P < 0.001, FGF7 vs EV group. (b, c) Cell invasion was examined in A549 cells transiently transfected with the NC mimic, miR-107 mimic, and miR-107 mimic plus pcDNA3.1-FGF7. ∗∗∗P < 0.001, miR-107 mimic vs NC mimic group; ###P < 0.001, miR-107 inhibitor vs NC inhibitor group. (d, e) E-cadherin and vimentin levels were measured by RT-qPCR in A549 cells transiently transfected with the NC mimic, miR-107 mimic, and miR-107 mimic plus pcDNA3.1-FGF7. ∗∗∗P < 0.001, miR-107 mimic vs NC mimic group; ##P < 0.01, miR-107 + FGF7 vs miR-107 mimic group. (f) The model showing a molecular mechanism underlying circCCT3-mediated metastasis of NSCLC.