Table 3.
Risk factors for graft loss in first and second transplantation.
| HR | 95% CI | p value | |
|---|---|---|---|
| Number of transplantations | |||
| 1 | Ref | ||
| 2 | 1.5 | 1.1–2.0 | 0.003 |
| ≥3 | 3.3 | 1.7–6.1 | <0.001 |
|
| |||
| Recipient age (years) | |||
| <50 | Ref | ||
| 50–59 | 1.2 | 0.9–1.6 | 0.1 |
| 60–69 | 1.9 | 1.4–2.5 | <0.001 |
| ≥70 | 2.9 | 1.8–4.8 | <0.001 |
|
| |||
| Time on dialysis (years) | |||
| <1 | Ref | ||
| 1-2 | 1.2 | 0.9–1.5 | 0.2 |
| 2–4 | 1.4 | 1.1–1.8 | 0.003 |
| >4 | 1.7 | 1.3–2.2 | <0.001 |
|
| |||
| Charlson–Deyo index∗ | |||
| 2 (kidney disease only) | Ref | ||
| 3 (≤1 mild comorbidity) | 1.2 | 0.9–1.6 | 0.1 |
| 4 (≥2 mild or 1 moderate comorbidity) | 1.8 | 1.4–2.4 | <0.001 |
| ≥5 (multiple comorbidities) | 2.3 | 1.7–3.0 | <0.001 |
|
| |||
| Smoking | 1.3 | 1.1–1.5 | 0.01 |
|
| |||
| Comorbidities∗ | |||
| Myocardial infarction | 1.3 | 1.0–1.7 | 0.04 |
| Congestive heart failure | 3.1 | 2.1–4.5 | <0.001 |
| PAD | 1.4 | 1.0–1.8 | 0.03 |
| Diabetes with end organ failure | 1.2 | 1.0–1.3 | 0.02 |
| Moderate – severe liver disease | 1.3 | 1.0–1.6 | 0.04 |
Note. HR, hazard ratio; CI, confidence interval; PAD, peripheral artery disease. ∗Charlson–Deyo index was analyzed for scoring points and in a second model using the same confounders for underlying comorbidities to avoid interactions.