. 2021 Dec 18;414(18):5357–5371. doi: 10.1007/s00216-021-03819-1

Table 4.

Evaluation of the presence and absence of SH-SY5Y cells on identified carotenoids in cell medium before and after the treatment with Dunaliella salina extract at 20 μg/mL for 24 h (n = 5). Values are expressed as the AUC obtained by peak integration of DAD absorption spectrum of HPLC–DAD-MS/MS analysis. Different letters in same row indicate significant differences between samples after ANOVA with Tukey’s post hoc, p-value < 0.05

Carotenoid	Cells		Non-cells		Ratio 24 h/0 h
Carotenoid	0 h	24 h	0 h	24 h	Cells	Non-cells	t-test
Lutein	93 ± 5^a	54 ± 8^b	89 ± 16^a	49 ± 7^b	0.583	0.556	0.614
Zeaxanthin	40 ± 2^a	16 ± 2^b	40 ± 7^a	15 ± 3^b	0.394	0.386	0.848
Cryptoxanthin-type	68 ± 2^b	121 ± 15^a	68 ± 11^b	122 ± 16^a	1.786	1.805	0.899
Cryptoxanthin-type	92 ± 6^a	108 ± 14^a	79 ± 24^a	107 ± 19^a	1.171	1.347	0.206
all-trans-β-Carotene	513 ± 44^a	246 ± 38^b	637 ± 160^a	279 ± 32^b	0.479	0.437	0.335
9-cis-β-Carotene isomer	3787 ± 183^a	1468 ± 155^b	3557 ± 613^a	1405 ± 211^b	0.388	0.395	0.826

AUC, area under curve