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. 2022 Jun 29;13:3749. doi: 10.1038/s41467-022-31563-2

Fig. 1. Hemizygous depletion of MT1-MMP promotes insulin sensitivity in aged mice.

Fig. 1

In all, 18-months-old WT and Mmp14+/− mice on a chow diet were compared: a body weight and composition (n = 6), b fasting plasma glucose (n = 6), c fasting plasma insulin (n = 6), d glucose-tolerance test (n = 6), e insulin-tolerance test (n = 6), f WT and Mmp14+/- mice fed chow diet at the age of 18 months were challenged with insulin. The expression of phosphorylated Akt (pAkt) in relative to the level of total Akt (tAkt) in the livers, white adipose tissues (WAT) and muscles was examined by western blotting and quantified. (n = 3) Representative western blots were shown in Supplementary Fig. S4D. Data are reported as average ± s.e.m.; two-sided unpaired t test (a–c) one-way ANOVA (f) or two-way ANOVA (d, e). Source data are provided as a Source Data file.