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. 2022 Jun 29;5:634. doi: 10.1038/s42003-022-03596-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Upon pathogen re-exposure memory CD8 T cells become activated in the draining lymph nodes and b migrate to the site of infection to control the pathogen. c A proportion of the activated memory CD8 T cells migrates to antigen-free lymph nodes where they interact with naïve CD8 T cells resulting in acquisition of an activated/memory phenotypic properties by naïve CD8 T cells. The figure was created by BioRender under University of Pittsburgh license.