Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 29;13:3760. doi: 10.1038/s41467-022-31526-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 9 — a Superposition of xKCNQ1-CaM and xKCNQ1-CaM-ML277 with hKCNQ1 (PDB-ID: 6V01), xKCNQ1 (PDB-ID: 5VMS), hKCNQ2 (PDB-ID: 7CR0) and hKCNQ4 (PDB-ID: 7VNQ, PDB-ID: 7BYL) structures showing detail around Phe322 (xKCNQ1) in a top view from the extracellular side. The previously published xKCNQ1-CaM and hKCNQ2 and hKCNQ4 structures show a corresponding Phe322 side-chain orientation pointing towards the ML277 binding site, while hKCNQ1 and our structures show a Phe322 oriented toward the pore. b Cryo-EM densities for Phe322 in xKCNQ1-CaM and xKCNQ1-CaM-ML277 (above) from this study, and from hKCNQ1 (F332, PDB-ID: 6V01) and xKCNQ1-CaM (Phe322, PDB-ID: 5VMS), below. The contour level cut offs were: maps from this study 8x rmsd, EMD-20967 6x rmsd, EMD-8712 1x rmsd.