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. 2022 Jun 29;7:205. doi: 10.1038/s41392-022-01058-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — NK cell trafficking and homing at steady state. NK cells develop from HSCs in the BM parenchyma and gradually reach blood and peripheral tissues as they mature. CXCR4 is highly expressed in immature NK cells, including NKPs and iNKs, making NK cell remains in or homes back to the BM parenchyma. When CXCR4 expression is downregulated and the expression of CXCR3, CXCR6, S1P5 and CX3CR1 is upregulated, NK cells gradually egress from the BM and enter peripheral tissues via circulating blood. Created with BioRender.com