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. 2022 May 25;298(7):102071. doi: 10.1016/j.jbc.2022.102071

Figure 4.

Figure 4

Representative traces for coseeding and cross-seeding fibril formation and mean lag-times. Monomers of: Aβ42(Italian) (A); Aβ40(Arctic) (B); Aβ40(WT) (C); and Aβ42(WT) (D). Representative (median) trace (top) and mean lag-time (bottom) from n = 9 for each condition, error bars are SD. Seed free is presented in black, cross-seeding conditions with 10% fibrils are present as: Aβ40(WT) (blue); Aβ42(WT) (red); Aβ40(Italian) (purple); Aβ42(Italian) (green); Aβ40(Arctic) (yellow); and Aβ42(Arctic) (orange). Aβ monomers were 10 μM, in Hepes (30 mM) at pH 7.4, NaCl (160 mM). ANOVA, comparison between no-seed and seeded conditions. ∗∗∗∗p ≤ 0.0001, ∗∗∗p ≤ 0.001, ∗∗p ≤ 0.01. See supplementary Figures for n = 9 traces for each condition. Aβ, Amyloid-β.