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. 2022 May 25;298(7):102071. doi: 10.1016/j.jbc.2022.102071

Figure 7.

Figure 7

TEM images of both seeded and unseeded Aβ42(WT) and Aβ40(Arctic).A, Aβ40(Arctic); (B) Aβ42(WT); (C) Aβ40(Arctic) with 10% Aβ42(WT) fibril seeds; (D) Aβ42(WT) with 10% Aβ40(Arctic) fibril seeds. Aβ40(Arctic) with Aβ42(WT) fibril seeds added suggest cross-seeding as the Aβ42(WT) fibril seed induces a marked twist in the otherwise untwisted Aβ40(Arctic) fibril isoform. Aβ40(Arctic) fibril seeds cause a marked extension in the periodicity of the Aβ42(WT) fibril twist from 80 nm to 125 nm. The scale bar represents 50 nm. E, average twist periodicity for the four conditions. Aβ, Amyloid-β; TEM, transmission electron microscopy.