Fig. 1 –

(A) Risk of high-grade prostate cancer based on PSA for patients with (orange) and without (blue) a first-degree family history of prostate cancer with 95% confidence intervals. Note that there is no significant interaction between PSA and family history, so the effect of family history is consistent across PSA levels. (B) Probability of high-grade prostate cancer based on the number of first-degree relatives with prostate cancer. The solid line indicates no family history (blue), and the dashed lines indicate one (orange), and two or more (gray) affected relatives. Note that there is no significant interaction between PSA and family history, so the effect of family history is consistent across PSA levels.

PCA = first-degree prostate cancer; PSA = prostate-specific antigen.