Fig. 2 –

(A) Risk of high-grade prostate cancer based on PSA for patients with (orange) and without (blue) a first-degree family history of breast cancer with 95% confidence intervals. Note that there is no significant interaction between PSA and family history, so the effect of family history is consistent across PSA levels. (B) Risk of high-grade prostate cancer based on PSA for patients with a family history of both first-degree prostate and breast cancer (gray), only a first-degree prostate cancer family history (orange), only a first-degree breast cancer family history (pink), or no family history or either cancer (blue). Note that there is no significant interaction between PSA and family history, so the effect of family history is consistent across PSA levels. Family history of first-degree prostate cancer and first-degree breast cancer was reported in 99 patients.

BCA = first-degree breast cancer; PCA = first-degree prostate cancer family history; PSA = prostate-specific antigen.