Table 1 –
Characteristics of the Prostate Biopsy Collaborative Group cohort, and among the four sites (Zurich, UTHSCSA, San Juan VA, and Durham VA) with additional family history data availablea
| Characteristic | Overall (N = 20 323) | Detailed family history available (N = 4621) |
|---|---|---|
|
| ||
| Age at biopsy (yr) | 65 (60–70) | 65 (60–69) |
| Missing | 2 | 0 |
| Race | ||
| White | 11 505 (80) | 2605 (56) |
| Black | 2128 (15) | 1779 (39) |
| Other | 708 (4.9) | 229 (5.0) |
| Missing | 5982 | 8 |
| Prostate-specific antigen (ng/ml) | 6.4 (4.6, 9.8) | 6.0 (4.6, 8.7) |
| Abnormal digital rectal exam | 4474 (25) | 1507 (34) |
| Missing | 2482 | 217 |
| Prior negative biopsy | 2798 (21) | 924 (20) |
| Missing | 6933 | 0 |
| Biopsy Gleason grade group | ||
| Negative | 9552 (47) | 2089 (45) |
| 1 | 3682 (18) | 925 (20) |
| 2 | 3185 (16) | 770 (17) |
| 3 | 1491 (7.3) | 365 (7.9) |
| Gleason 7 unspecified | 159 (0.8) | 0 (0) |
| 4 | 924 (4.5) | 247 (5.3) |
| 5 | 1330 (6.5) | 225 (4.9) |
| MRI-guided biopsy | 1234 (6.1) | 318 (6.9) |
| First-degree prostate cancer family history | 2889 (18) | 888 (19) |
| Missing | 4524 | 2 |
| Type of first-degree prostate cancer family history | ||
| Father | – | 446 (50) |
| Brother | – | 352 (40) |
| Father and brother | – | 83 (9.4) |
| Son | – | 6 (0.7) |
| Missing | – | 3 |
| Number of first-degree prostate cancer relatives | ||
| 1 | – | 751 (85) |
| 2 | – | 108 (12) |
| 3 | – | 24 (2.7) |
| 4 | – | 4 (0.5) |
| Missing | – | 3 |
| Second-degree prostate cancer family history | – | 371 (8.0) |
| Missing | – | 6 |
| First-degree breast cancer family history | – | 348 (7.5) |
| Missing | – | 8 |
IQR = interquartile range; MRI = magnetic resonance imaging; UTHSCSA = University of Texas Health Science Center at San Antonio; VA = Veterans Affairs.
a
Additional data collected at these sites include the number of first- and second-degree relatives with a family history of prostate or breast cancer. Median (IQR) and n (%) are shown for continuous and categorical variables, respectively.