TABLE 4.

Univariate and multivariable competing risk analyses for cardiovascular death (CVD) among patients with colorectal cancer (CRC) in the training cohort.

	Univariate analysis		Multivariate analysis
Variables	sdHR (95% CI)	P	sdHR (95% CI)	P
Age
<65	Reference		Reference
≥65	5.80 (5.42–6.21)	<0.001	4.65 (4.34–4.99)	<0.001
Sex
Female	Reference
Male	1.04 (0.99–1.10)	0.077
Race
Black	Reference		Reference
White	1.07 (0.993–1.15)	0.07	0.94 (0.87–1.01)	0.095
Others	0.70 (0.62–0.78)	<0.001	0.67 (0.60–0.76)	<0.001
Marital status
Married	Reference		Reference
Unmarried	1.63 (1.55–1.71)	<0.001	1.33 (1.26–1.40)	<0.001
Insurance
Insured	Reference		Reference
Any Medicaid	2.81 (2.26–3.51)	<0.001	1.25 (1.00–1.56)	0.051
Uninsured	2.65 (2.14–3.27)	<0.001	1.01 (0.81–1.25)	0.940
Tumor site
Left	Reference		Reference
Right	1.10 (0.90–1.33)	0.35	0.96 (0.79–1.17)	0.710
NOS	0.75 (0.62–0.91)	0.003	0.94 (0.77–1.14)	0.520
Tumor size
≤5 cm	Reference		Reference
5–10 cm	1.01 (0.96–1.07)	0.710	1.07 (1.01–1.14)	0.017
>10 cm	0.85 (0.80–0.91)	<0.001	0.99 (0.92–1.07)	0.810
Grade
Grade I	Reference
Grade II	1.016 (0.94–1.10)	0.69
Grade III	0.94 (0.86–1.04)	0.22
Grade IV	0.86 (0.72–1.02)	0.08
SEER stage
Localized	Reference		Reference
Regional	0.786 (0.75–0.83)	<0.001	0.99 (0.94–1.05)	0.930
Distant	0.334 (0.31–0.37)	<0.001	0.47 (0.43–0.52)	<0.001
Surgery
No	Reference		Reference
Yes	1.24 (1.13–1.36)	<0.001	0.81 (0.72–0.90)	<0.001
Radiotherapy
No	Reference		Reference
Yes	0.47 (0.43–0.52)	<0.001	1.01 (0.91–1.13)	0.780
Chemotherapy
No	Reference		Reference
Yes	0.30 (0.28–0.32)	<0.001	0.48 (0.45–0.52)	<0.001

sdHR, subdistribution hazard ratio; CI, confidence interval; Other, American Indian/Alaska Native/Asian/Pacific Islander; NOS, not otherwise specified; SEER, Surveillance, Epidemiology, and End Results; CRC, colorectal cancer; CVD, cardiovascular death.