Table 5.
Multivariable logistic regression models predicting poor discharge outcome (NIS-SOM) by US region.
| Variable | Adjusted odds ratio estimates (95% confidence intervals) | P value | ||||
|---|---|---|---|---|---|---|
| Year of admission: 2014–2018 versus 2009–2013 | 0.69 (0.66–0.71) | <0.0001 | ||||
| Northeast | Midwest | South | West | Main effect | Regional interaction Effect | |
| Aneurysm repair | 0.001 | |||||
| Endovascular coiling | 0.96 (0.87–1.07) | 1.14 (1.03–1.27) | 0.84 (0.77–0.92) | 0.96 (0.84–1.11) | 0.605 | |
| Surgical clipping | 0.96 (0.87–1.07) | 0.90 (0.82–0.98) | 0.88 (0.81–0.95) | 0.82 (0.74–0.90) | ||
| Age, per year | 1.05 (1.04–1.05) | 1.05 (1.04–1.05) | 1.05 (1.04–1.05) | 1.04 (1.04–1.05) | <0.0001 | 0.171 |
| Presence of a comorbidity flaga | 1.181(1.07–1.30) | 1.28 (1.16–1.42) | 1.16 (1.06–1.26) | 1.28 (1.14–1.45) | 0.001 | 0.305 |
| Severity of illness (SOI) on admissionb | ||||||
| Moderate SOI | 1.91 (1.54–2.4) | 2.02 (1.60–2.54) | 1.91 (1.56–2.34) | 1.70 (1.24–2.33) | <0.0001 | <0.0001 |
| Major SOI | 3.05 (2.50–3.73) | 3.98 (3.21–4.93) | 3.28 (2.73–3.96) | 3.34 (2.50–4.47) | ||
| Extreme SOI | 18.49(15.1–22.7) | 22.6 (18.2–28.1) | 21.8 (18.1–26.3) | 18.7 (13.9–25.2) | ||
| Presence of a complication flagc | 2.98 (2.78–3.20) | 3.08(2.878–3.30) | 3.08 (2.90–3.27) | 3.01 (2.76–3.28) | <0.0001 | 0.886 |
| Nimodipine use | 0.43 (0.38–0.50) | 0.48 (0.42–0.55) | 0.39 (0.34–0.43) | 0.49 (0.42–0.58) | <0.0001 | 0.025 |
| Vasopressor used | 1.63 (1.44–1.84) | 1.75 (1.55–1.97) | 1.81 (1.63–2.01) | 1.79 (1.54–2.08) | <0.0001 | 0.615 |
| Use of intra-arterial vasodilator therapye | 0.65 (0.57–0.74) | 0.70 (0.63–0.79) | 0.66 (0.60–0.73) | 0.65 (0.56–0.75) | <0.0001 | 0.771 |
SOI, Severity of Illness. aDefined as any medical comorbidity prior to ictus. bDefined by the All Patients Refined Diagnosis Related Groups (APR-DRG) disease-specific risk of mortality severity index; reference group: Minor SOI. cDefined as any hospital complication during admission. dIncluded intravenous norepinephrine, epinephrine, dopamine, vasopressin, dobutamine, milnirone. eIncluded intra-arterial nicardipine, verapamil, milnirone, papaverine.