TABLE 2.
Baseline Demographic and Clinical Data
| Demographic and Clinical Data | Died in ICU (n = 21) | Survived ICU (n = 57) | All Patients | p |
|---|---|---|---|---|
| Age, yr, mean (sd) | 57.0 (11.7) | 60.6 (12.6) | 59.6 (12.4) | 0.26 |
| Gender, n (%) | ||||
| Female | 6 (35.3) | 11 (64.7) | 17 (100.0) | 0.38 |
| Male | 15 (24.6) | 46 (75.4) | 61 (100.0) | |
| Sequential Organ Failure Assessment score, mean (sd) | 8.7 (3.7) | 7.6 (2.9) | 7.9 (3.2) | 0.17 |
| Comorbid conditions, n (%) | ||||
| Cerebrovascular accident | 6 (28.6) | 15 (71.4) | 21 (100.0) | 0.84 |
| Chronic lung disease | 5 (17.9) | 23 (82.1) | 28 (100.0) | 0.18 |
| Diabetes | 5 (22.7) | 17 (77.3) | 22 (100.0) | 0.60 |
| Hypertension | 19 (27.5) | 50 (72.5) | 69 (100.0) | 0.74 |
| Immunocompromise | 7 (36.8) | 12 (63.2) | 19 (100.0) | 0.26 |
| Liver disease | 2 (33.3) | 4 (66.7) | 6 (100.0) | 0.71 |
| Cumulative compliance score | 6.8 (1.8) | 6.0 (1.5) | 6.2 (1.6) | 0.04 |
| Compliance grade, n (%) | ||||
| Compliant | 8 (21.1) | 30 (78.9) | 38 (100.0) | 0.44 |
| Moderately compliant | 7 (29.2) | 17 (70.8) | 24 (100.0) | |
| Poorly compliant | 6 (37.5) | 10 (62.5) | 16 (100.0) | |
| Norepinephrine equivalence dose at start of Ang II, µg/kg/min (sd) | 0.33 (0.17) | 0.30 (0.13) | 0.31 (0.14) | 0.43 |
| Vasopressin dose at start of Ang II, U/min (sd) | 0.10 (0.07) | 0.12 (0.05) | 0.11 (0.05) | 0.24 |
| Ang II starting dose, ng/kg/min (sd) | 19.0 (17.7) | 16.4 (11.0) | 17.1 (13.1) | 0.43 |
| Methylene blue, n (%) | ||||
| Used | 4 (26.7) | 11 (73.3) | 15 (100.0) | 0.98 |
| Not used | 17 (27.9) | 46 (73.0) | 63 (100.0) | |
| Hydroxocobalamin, n (%) | ||||
| Used | 11 (34.4) | 21 (65.6) | 32 (100.0) | 0.22 |
| Not used | 10 (21.7) | 36 (78.3) | 46 (100.0) | |
| Mechanical circulatory support, n (%) | ||||
| Used | 16 (32.7) | 33 (67.3) | 49 (100.0) | 0.14 |
| Not used | 5 (17.2) | 24 (82.8) | 29 (100.0) | |
| Operative data | ||||
| Cardiopulmonary bypass time, min (sd) | 267.1 (70.7) | 203.9 (85.5) | 220.3 (86.1) | 0.004 |
| Cross-clamp time, min (sd) | 183.4 (68.1) | 166.2 (70.0) | 170.6 (69.4) | 0.36 |
| Serum lactate prior to Ang II, mg/dL (sd) | 8.9 (5.0) | 7.0 (3.6) | 7.5 (4.2) | 0.08 |
| ICU LOS, d (sd) | 16.5 (20.4) | 16.2 (11.3) | 16.3 (14.2) | 0.94 |
| Hospital LOS, d (sd) | 19.5 (22.3) | 27.5 (17.2) | 25.4 (18.9) | 0.10 |
Ang II = angiotensin II, LOS = length of stay.
χ2 and analysis of variance analyses reported with an alpha of 0.05.