TABLE 3.
Main pharmacokinetic parameters after taking a single oral dose of relugolix with or without daidzein to rats (n = 6).
| Parameters | Relugolix | Relugolix + daidzein |
|---|---|---|
| T1/2 (h) | 8.95 ± 0.75 | 8.45 ± 1.30 |
| Tmax (h) | 2.33 ± 0.82 | 2.42 ± 0.92 |
| Cmax (ng/mL) | 350.17 ± 190.35 | 295.70 ± 135.01 |
| CL (L/h•kg) | 5.50 ± 3.29 | 6.62 ± 3.44 |
| AUC0→t (ng/mL•h) | 2743.18 ± 1353.80 | 2157.35 ± 964.50 |
| AUC0→∞ (ng/mL•h) | 2813.49 ± 1390.68 | 2196.56 ± 975.10 |
T1/2, half-life time; Cmax, maximum plasma concentration; Tmax, time to Cmax; CL, clearance; AUC, Area under the concentration-time curve; MRT, mean residence time.