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. 2022 Jun 16;13:887876. doi: 10.3389/fphar.2022.887876

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Copyright © 2022 Jiang, Hong and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis of differentially expressed proteins (DEPs) in CBS-treated HK-2 cells. (A) Volcano plot visualization of DEPs (fold of change >2 or <0.5, p value <0.05) in HK-2 cells treated with 500 μM CBS for 48 h, and 138 and 174 proteins were up and downregulated among 6,230 proteins, respectively. (B) Enrichment analysis of DEPs in CBS-treated HK-2 cells, in perspective of KEGG, and (C) GO cellular component, molecular function, and biological process. (D) Protein–protein interaction networks of both up and downregulated DEPs generated using STRING. (E) Volcano plots visualizing DEPs involved in GO terms: actin cytoskeleton and secretory granule. CBS-induced proteomic alterations in GSH-depleted HK-2 cells.