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. 2022 Jun 16;13:887876. doi: 10.3389/fphar.2022.887876

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Copyright © 2022 Jiang, Hong and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bismuth mitigates the toxicity of soft metal compounds but not oxidants or hard metal compounds. CBS pretreatment increases the LD50 of HK-2 cells against soft metallodrugs and pollutants: (A) carboplatin, (B) arsenic trioxide (As₂O₃), (C) arsenic pentoxide (As₂O₅), (D) antimony citrate (SbCit), (E) cadmium chloride (CdCl₂), and (F) mercury chloride (HgCl₂). CBS pretreatment did not increase the LD50 of HK-2 against oxidants: (G) hydrogen peroxide (H₂O₂) and (H) sodium chromate (Na₂CrO₄). (I) CBS did not increase the LD50 of HK-2 against titanocene dichloride. HK-2 cells were treated without or with 500 μM CBS for 48 h, before further treatment with different compounds at different doses for 24 h. LD50s are determined by logistic fit.