Table 1.

Study outcomes and data collection method.

Outcomes	Data source	Timepoint
Primary Outcome Migraine days per 28 days	M-sense electronic diary	Baseline vs. month 6
Secondary outcomes
Responder rate (patients with ≥50% reduction from baseline in migraine days/month)	M-sense electronic diary	First six months in the study
Headache days per 28 days	M-sense electronic diary	Baseline vs. month 6
Days of acute medication intake	M-sense electronic diary	Baseline vs. month 6
HIT-6 score	Study databank	Baseline vs. month 6
EQ-5D-5L score	Study databank	Baseline vs. month 6
PROMIS 29 scores	Study databank	Baseline vs. month 6
Overall health care costs	Claims' data	Six months prior study initiation versus six months after study initiation
Days with inability to work	Claims' data	Six months prior study initiation versus six months after study initiation

HIT-6, Headache Impact-Test 6; PROMIS 29, Patient-Reported Outcome-measurement Information System.