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(A) Scheme of the nested k-fold cross-validation (for k outer = 5 and k inner = 5). The nested fitting procedure was repeated 100 times with different random permutations of the discovery dataset. (B) Majority voting for the ensemble of classifiers used for testing on the external test cohort (the dashed red lines denote the decision thresholds optimized according to the inner CV loop). (C) Workflow of the radiomics pipeline for CRS prediction.
