TABLE 1.

Study characteristics and patient baseline characteristics.

Study	Country	Study design	CDT type	PERT	CDT			ST			NOS score
					No of patients	Age	Sex, male	No of patients	Age	Sex, male
Beyer et al. (18)	United States	Retrospective study	Catheter-directed thrombolysis, US-assisted thrombolysis	NS	2,060	60.0 ± 15.2	1,045 (50.7%)	3,376	59.2 ± 15.9	1,724 (51.1%)	8
D’Auria et al. (17)	United States	Retrospective study	Catheter-directed thrombolysis, US-assisted thrombolysis	NS	99	57.8 ± 12.2	46 (46.5%)	240	62.5 ± 13.7	121 (50.4%)	8
Geller et al. (20)	United States	Retrospective study	Catheter-directed thrombolysis	NS	632	57.2 ± 16.2	344 (54.4%)	1,283	57.4 ± 16.3	652 (50.9%)	7
Harrison et al. (15)	United States	Retrospective study	Catheter-directed thrombolysis	Yes	18	73.8 ± 6.19	NS	108	75.5 ± 7.99	NS	8
Hennemeyer et al. (13)	United States	Retrospective study	US-assisted thrombolysis, aspiration thrombectomy	NS	36	59 ± 15.93	17 (47.2%)	43	60 ± 17.16	20 (46.5%)	7
Khaing et al. (20)	United States	Retrospective study	Catheter-directed thrombolysis, aspiration thrombectomy	Yes	16	50.5 ± 10.2	6 (37.5%)	30	61 ± 8.9	13 (43.3%)	8
Kucher et al. (7)	Germany	Multicenter randomized, controlled trial	US-assisted thrombolysis	NS	30	64 ± 15	11 (36.7%)	29	62 ± 13	17 (58.6%)	9
Patel et al. (16)	United States	Retrospective study	Catheter-directed thrombolysis	NS	352	59.59 ± 15.24	169 (48.0%)	1,169	58.44 ± 16.07	496 (42.4%)	8
Percy et al. (14)	United States	Retrospective study	Not specified	NS	22,336	62 ± 24	11,282 (50.5%)	33,553	58 ± 23	16,907 (50.4%)	8
Sharifi et al. (21)	United States	Retrospective study	US-assisted thrombolysis	NS	47	59 ± 14	27 (57.4%)	50	61 ± 13	29 (58.0%)	8
Yoo et al. (22)	South Korea	Retrospective study	Catheter-directed thrombolysis	NS	28	61.5 ± 17.3	13 (46.4%)	44	65.5 ± 16.8	9 (20.5%)	8

CDT, catheter-directed therapies; NOS, Newcastle–Ottawa score; NS, not specified; PERT, pulmonary embolism response team; ST, systemic thrombolysis; US, ultrasound.