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. 2022 Jun 16;12:887257. doi: 10.3389/fonc.2022.887257

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Copyright © 2022 Chi, Yao, Chen, Liu, He, Zhang, Ellies, Wu, Zhao, Zhou, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BCAA metabolic remodeling is strongly associated with breast cancer prognosis. (A-C) mRNA expression levels of BCAA catabolic enzymes were analyzed by Oncomine database: (A) BCAT2, (B) BCKDK, (C) PPM1K. (D) Kaplan-Meier RFS curves stratified by BCAT2 expression levels in 392 TNBC patients. The mean BCAT2 mRNA value was used to assign patients to two subgroups (ID203576 at). (E) Kaplan-Meier RFS curves stratified by BCKDK expression levels in 392 TNBC patients. The mean BCKDK mRNA value was used to assign patients to two subgroups (ID202030 at). (F) Kaplan-Meier RFS curves stratified by PPM1K expression levels in 176 TNBC patients. The mean PPM1K mRNA value was used to assign patients to two subgroups (ID244011 at). Mean ± SD, ***p < 0.001, Student’s t-test.