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. 2022 Jun 16;12:887257. doi: 10.3389/fonc.2022.887257

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Copyright © 2022 Chi, Yao, Chen, Liu, He, Zhang, Ellies, Wu, Zhao, Zhou, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High BCAA inhibits the lung metastasis of breast cancer. (A) Representative images of H&E staining of lung tissues from tumor-bearing Pp2cm-WT/KO mice. (B) Statistical analysis of the total number of lung metastases (WT, n=8; Pp2cm-KO, n=10). (C) Statistical analysis by size of metastases. (D) A lung metastasis mouse model of breast cancer by the tail vein injection in mice fed low BCAA diet (LBCAA) or normal BCAA diet (NBCAA) (E) Detection of lung metastases at 13th day by Bioluminescence Imaging in mice from D (NBCAA, n=10; LBCAA, n=11). (F) Statistics of caudal vein lung metastasis. Mean ± SD, *p < 0.05, Student’s t-test.