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. 2022 Jun 16;12:887257. doi: 10.3389/fonc.2022.887257

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Copyright © 2022 Chi, Yao, Chen, Liu, He, Zhang, Ellies, Wu, Zhao, Zhou, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High BCAA inhibits the ability of breast cancer cell migration, invasion, and the expression of N-Cadherin. (A) Migration ability of LM2 cells treated with different concentrations of BCAA analyzed by transwell assay (22 hours). (B) Statistics of the number of migration cells in transwell assay. All BCAA treated groups (50μM, 100μM, 200μM, 800μM) were compared with 25μM BCAA group. ***p < 0.001, one-way ANOVA. (C) Wound healing assay was used to detect the migration ability of LM2 cells treated by different concentrations of BCAA (48 hours). (D) Statistics of the mobility ratio in wound healing assay. (E) Invasion ability of LM2 cells treated by different concentrations of BCAA was detected by transwell assay (22 hours). (F) Statistics of the number of invasion cells in transwell assay. All BCAA treated groups (50μM, 100μM, 200μM, 800μM) were compared with 25μM BCAA group. **p < 0.01, ANOVA. (G) N-Cadherin, E-Cadherin, Vimentin, and Slug expression was analyzed by Western blot in LM2 cells. (H) E-Cadherin, N-Cadherin, and Vimentin expression in tumor tissues was detected by Western blot.