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. 2022 Jun 16;13:911105. doi: 10.3389/fphar.2022.911105

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Copyright © 2022 Viero, Rodrigues, Frare, Da Silva, Ferreira, Da Silva, Pereira, Ferreira, Pillat, Bocchi, Nassini, Geppetti and Trevisan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CGRP antagonist reduced migraine-like behaviors induced by unpredictable stress model in mice. BIBN4096BS (olcegepant, 100 mg/kg) intraperitoneal (i.p.) administration reduced the (A,B) hind paw mechanical allodynia (D,E) periorbital mechanical allodynia (PMA), and (G,H) grimacing pain behavior in male and female stressed (ST) mice when compared to vehicle (Veh) treated group. Antinociceptive effect of BIBN4096BS at 1 h after treatment for (C) hind paw mechanical allodynia (F) PMA, and (I) grimacing pain behavior. Baseline measurements (described as B in the graph) were observed before induction. Time 0 represents the measures taken 7 days after ST or in the NST group. The arrow represents the treatment or veh injection. Spontaneous nociception was analyzed by the mouse grimace scale (MGS). Data are expressed as mean ± S.E.M. (n = 8). *p < 0.05, when compared vehicle/stressed group (ST) or between the sexes within the ST group. ^# p < 0.05 when compared to the NST group ^§ p < 0.05 when compared to the vehicle (Veh) treated group [repeated measures two-way ANOVA followed by Bonferroni’s post hoc test].