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. 2022 Jun 16;13:911105. doi: 10.3389/fphar.2022.911105

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Copyright © 2022 Viero, Rodrigues, Frare, Da Silva, Ferreira, Da Silva, Pereira, Ferreira, Pillat, Bocchi, Nassini, Geppetti and Trevisan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CGRP antagonist reverts the anxiety-like symptoms and increased exploratory activity after unpredictable sound stress. BIBN4096BS (olcegepant, 100 mg/kg) intraperitoneal (i.p.) administration reverted the alterations of different behavioral parameters: Time spent (A) grooming (B) sniffing (C) rearing (D) the number of crossings (E) representative image of crossings represented by track plot (F) time in the peripheral zone were observed in the open field test at day 7 post-stress (ST group) or in non-stressed group (NST) 1 hour-post BIBN4096BS administration. (G) Representative image of time in the peripheral zone represented by heat map. Data are expressed as mean ± S.E.M. (n = 8). *p < 0.05, when compared between the sexes within the ST group. ^# p < 0.05 when compared to the NST group. ^§ p < 0.05 when compared to the vehicle (Veh) treated group [repeated measures two-way ANOVA followed by Bonferroni’s post hoc test].