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Model for the mechanism of HCMV RNA2.7 in cell cycle control. RNA2.7 binds to Pol II and inhibits Pol II S2 phosphorylation by blocking interactions between pCDK9 and Pol II. The inhibition of Pol II S2 phosphorylation decreases the levels of MCMs, Cdt1 and Cdc6, and disturbs the formation of pre-RC which leads to host cell cycle arrest at G0/G1 phase and facilitates viral DNA replication.
