Table 2.
Target proteins | Fungal-unique | Mammalian homolog | The proportion of amino acid sequence identity |
---|---|---|---|
Spt14 | No | PIG-A | 40% (S. cerevisiae) |
Gwt1 | No | PIG-W | 30% (S. cerevisiae) |
Mcd4 | No | PIG-N | 36% (S. cerevisiae) |
Chitin synthases | Yes | – | – |
Sec14 | No | SEC14-like protein 1 | 11% (S. cerevisiae) |
IPC synthase | Yes | – | – |
Hsp90 | No | HSP 90-alpha | 60% (S. cerevisiae) |
HSP 90-beta | 61% (S. cerevisiae) | ||
Histone deacetylase 2 | Yes | – | – |
Eno1 | No | Alpha-enolase | 63% (S. cerevisiae) |
Dihydrolactate dehydrogenase | No | Dihydroorotate dehydrogenase | 30% (Aspergillus) |