Koike 1999.

Methods	Randomised, placebo‐controlled trial, single centre, unpublished
Participants	98 infertile women at risk of severe OHSS ( 43 albumin plus saline versus 55 saline alone) undergoing IVF/ICSI/GIFT > 20 oocytes were retrieved from patients at high risk.The estradiol in their serum was not measured Age (32.1 versus 31.0 years) Duration of infertility (not stated) No. of hMG ampoules (not stated) No. of oocytes (27 versus 26.1) No. of embryos (19 versus 17)
Interventions	Study group: 37.5 g albumin plus 1000 mL electrolyte solution just after oocyte retrieval Duration: consecutive 3 days Control group: 1000 mL electrolyte solution for consecutive 3 days
Outcomes	Method of diagnosing severe OHSS: marked haemoconcentration (haematocrit ≥ 45) and/or hypoproteinaemia (serum total protein < 6.0 g/dL) in addition to marked ascites on the upper abdomen at least 4 days after oocyte retrieval (Orvieto and Ben‐Rafael,1998) Severe OHSS: 13/43 versus 21/55 Pregnancy: 14/43 versus 24/55 Method of diagnosing pregnancy: serum β‐hCG Tolerability: not stated Safety: not stated Cost‐benefit: not stated
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random number table
Allocation concealment (selection bias)	Unclear risk	Methods not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Blinding not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	All randomised women included in analysis
Selective reporting (reporting bias)	Unclear risk	Adverse effects not reported as an outcome
Other bias	Unclear risk	No other potential bias identified