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. 2022 Jun 27;54(6):834–847. doi: 10.1038/s12276-022-00791-3

Fig. 3. TAS1 facilitates tumor growth and metastasis in vivo.

Fig. 3

a Image of subcutaneous xenograft tumors formed by KYSE150 and TE-11 cells transduced with shTAS1 #1, shTAS1 #2 or shCtrl in nude mice. (n = 5). b, c Subcutaneous tumor volume curve and statistical analysis of the weight of tumors formed by KYSE150 and TE-11 cells treated as indicated (n = 5). d Image of popliteal lymph nodes harvested 8 weeks after injection of KYSE150 and TE-11 cells with lentiviral shRNA vector-mediated TAS1 KD into the left footpads of nude mice (n = 6). e Statistical analysis of the incidence of popliteal lymph node metastasis in the indicated groups (chi-square test, two-sided). f Representative images of whole-body in vivo bioluminescence and H&E staining (scale bar, 100 μm) in lung sections from mice injected via the tail vein with KYSE150 and TE-11 cells with stable TAS1 (#1 and #2) knockdown or control (Ctrl) cells on Day 56 postinjection. g. Statistical analysis of the metastatic lung nodules confirmed by H&E staining (n = 5). The data are presented as the mean±S.D. values. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.