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. 2022 Jun 27;54(6):834–847. doi: 10.1038/s12276-022-00791-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Images of ex vivo tumors from the ESCC PDX model (n = 5). b, c Tumor volume curve and statistical analysis of the tumor weight of the PDX tumors. d Representative images of H&E staining and immunohistochemical staining for Ki67, TMPO, CyclinD1 and MTA1 in randomly selected PDX tumors from each group. Scale bar, 100 μm. e Statistical analysis of the Ki67 proliferation index (n = 5). f Statistical analysis of the immunohistochemical scores for the indicated genes (n = 5). The data are presented as the mean±S.D. values. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant.