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. 2022 Jun 30;23:41. doi: 10.1186/s12868-022-00723-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3: — a Results of physical performance test regarding peak oxygen uptake (VO2_peak), b peak respiratory exchange ratio (RER_peak), c heart rate @ 9 km/h and 3d) lactate @ 9 km/h. Chronic effects over TIME are displayed on the left, exercise PROTOCOL effects on the right, respectively. Means are indicated in black line or bar graphs, female individuals are shown in red shades, male individuals in blue shades. TIME effects are presented for assessments during baseline data collection (BDC), at the beginning of isolation (ISO1), at midterm (ISO2/3), at the end (ISO4) and during the recovery phase (R). For exercise PROTOCOL effects comparing interval (INT, stripped bars) and continuous (CON, full bars) protocols, the mean at the beginning (INT1, CON1) and end (INT2, CON2) of each protocol is displayed. Error bars indicate standard deviation. Significant differences to BDC are indicated by *, to ISO1 by $, and to R by †