Table 1.

Inclusion and exclusion criteria

PICO	Inclusion criteria	Exclusion criteria
Patient	Cancer patients (all entities and stages) Adult patients	Patients with precancerous conditions or carcinoma in situ Study population with more than 20% children under the age of 18 Primary prevention Preclinical studies
Intervention	Every intervention with hyperthermia in complementary medicine (hyperthermia treatments, which do not meet the defined quality criteria of the European Society for Clinical Oncology: whole-body-hyperthermia, hyperthermia with extracorporeal circulation, electro hyperthermia)
Comparison	All possible control groups (active control, placebo, standard, guideline, usual care, wait list)
Outcome	Mortality (overall survival) Morbidity (progression/disease-free interval, tumour response) Patient-reported outcomes (i.e. quality of life or other important psychological outcomes) Toxicity and adverse events (CTCAE) Laboratory parameters
Others	Language: German and English Full publication	Gray literature (conference articles, abstracts, letters, ongoing studies, unpublished literature…)